(19)
(11) EP 0 159 497 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
13.04.1988 Bulletin 1988/15

(43) Date of publication A2:
30.10.1985 Bulletin 1985/44

(21) Application number: 85102406

(22) Date of filing: 04.03.1985
(84) Designated Contracting States:
BE CH DE FR GB IT LI NL

(30) Priority: 09.03.1984 JP 4529284

(71) Applicant: KABUSHIKI KAISHA YAKULT HONSHA
 ()

(72) Inventor:
  • Endo, Akira
     ()

   


(54) Collagenase and production method thereof


(57) @ Disclosed herein is a novel collagenase "discolysin". It is useful for biochemical researches and the treatment of many diseases caused by collagen, such as hernia of intervertebral disc. It can be produced by culturing a discolysin-producing bacterium belonging to genus of Streptomyces in a culture medium and then collecting discolysin from the culture medium.






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