(19)

(11)

EP 0 168 425 A1

(12)

(43) Date of publication: 22.01.1986 Bulletin 1986/04 (21) Application number: 85900428.0 (22) Date of filing: 18.12.1984

(51) International Patent Classification (IPC):  C07C 69/ 30( . ) A61K 38/ 00( . ) A61K 31/ 23( . ) (86) International application number: PCT/US1984/002073 (87) International publication number: WO 1985/003002 (18.07.1985 Gazette 1985/16)

(84) Designated Contracting States: BE CH DE FR GB LI SE (30) Priority: 16.01.1984 US 19840571021 (71) Applicants: BAXTER TRAVENOL LABORATORIES, INC. Deerfield, IL 60015 (US) NEW ENGLAND DEACONESS HOSPITAL Boston, MA 02215 (US)	(72) Inventors: BLACKBURN, George, L. Jamaica Plain, MA 02130 (US) BABAYAN, Vigen, K. Waban, MA 02168 (US) BISTRIAN, Bruce, R. Ipswich, MA 01938 (US) MOLDAWER, Lyle, L. Waban, MA 02168 (US) COTTER, Richard Libertyville, IL 60048 (US) (74) Representative: MacGregor, Gordon, et al  ERIC POTTER CLARKSON St. Mary's Court St. Mary's Gate Nottingham, NG1 1LE Nottingham, NG1 1LE (GB)