(19)

(11)

EP 0 172 233 A1

(12)

(43) Date of publication: 26.02.1986 Bulletin 1986/09 (21) Application number: 85901218.0 (22) Date of filing: 14.02.1985

(51) International Patent Classification (IPC):  A61K 31/ 557( . ) C07C 401/ 00( . ) C12P 31/ 00( . ) C07C 67/ 00( . ) C07C 405/ 00( . ) (86) International application number: PCT/US1985/000226 (87) International publication number: WO 1985/003706 (29.08.1985 Gazette 1985/19)

(84) Designated Contracting States: CH DE FR GB LI (30) Priority: 14.02.1984 US 19840579933 (71) Applicant: UNIVERSITY OF HAWAII Honolulu, Hawaii 96822 (US)	(72) Inventors: FUKUSHIMA, Masanori 1-22, Shinpo-cho Aichi-ken 464 (JP) KUROZUMI, Seizi Kokubunji-shi Tokyo 185 (JP) SCHEUER, Paul, J. Honolulu, HI 96822 (US) YU, Patrick, T., K. Honolulu, HI 96814 (US) (74) Representative: Votier, Sidney David, et al  CARPMAELS & RANSFORD 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)