(19)

(11)

EP 0 185 701 A1

(12)

(43) Date of publication: 02.07.1986 Bulletin 1986/27 (21) Application number: 85902763.0 (22) Date of filing: 08.05.1985

(51) International Patent Classification (IPC):  C12N 11/ 12( . ) C12N 11/ 04( . ) C12P 21/ 00( . ) C12R 1/ 91( . ) C12N 5/ 02( . ) C12N 11/ 10( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1985/000838 (87) International publication number: WO 1985/005630 (19.12.1985 Gazette 1985/27)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 01.06.1984 US 19840616534 (71) Applicant: KARYON TECHNOLOGY, INCORPORATED Norwood, MA 02062 (US)	(72) Inventors: VASINGTON, Paul, John Norwood, MA 02062 (US) LYNCH, Maurice, Mark Warwick, RI 02889 (US) FRYE, Maureen, Elizabeth Mansfield, MA 02048 (US) (74) Representative: Bass, John Henton  REDDIE & GROSE 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)