(19)

(11)

EP 0 190 127 A1

(12)

(43) Date of publication: 13.08.1986 Bulletin 1986/33 (21) Application number: 84903279.0 (22) Date of filing: 10.08.1984

(51) International Patent Classification (IPC):  C07K 5/ 08( . ) A61K 39/ 39( . ) C07K 1/ 113( . ) C07K 7/ 06( . ) C07K 16/ 06( . ) A61K 38/ 00( . ) C07K 1/ 04( . ) C07K 5/ 10( . ) C07K 7/ 08( . ) (86) International application number: PCT/EP1984/000242 (87) International publication number: WO 1986/001211 (27.02.1986 Gazette 1986/05)

(84) Designated Contracting States: AT BE CH DE FR GB LI NL SE (71) Applicant: MERCK PATENT GmbH D-64271 Darmstadt (DE)	(72) Inventor: HAHN, Gary, Scott Solana Beach, CA 92075 (US) (74) Representative: Armitage, Ian Michael  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)