(19)

(11)

EP 0 190 335 A1

(12)

(43) Date of publication: 13.08.1986 Bulletin 1986/33 (21) Application number: 85904370.0 (22) Date of filing: 26.08.1985

(51) International Patent Classification (IPC):  G01N 33/ 543( . ) C12Q 1/ 00( . ) G01N 33/ 549( . ) C12M 1/ 34( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1985/001614 (87) International publication number: WO 1986/001603 (13.03.1986 Gazette 1986/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 28.08.1984 US 19840644903 (71) Applicant: HYBRITECH INCORPORATED San Diego California 92126 (US)	(72) Inventor: LIU, Lynne, Hlselick San Diego, CA 92131 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)