(19)

(11)

EP 0 191 049 A1

(12)

(43) Date of publication: 20.08.1986 Bulletin 1986/34 (21) Application number: 85903854.0 (22) Date of filing: 30.07.1985

(51) International Patent Classification (IPC):  C12N 15/ 00( . ) C07K 1/ 22( . ) C07K 14/ 195( . ) C12N 5/ 00( . ) C12P 5/ 00( . ) C12P 21/ 08( . ) A61K 39/ 00( . ) C07K 14/ 005( . ) C07K 16/ 00( . ) C12N 15/ 02( . ) C12P 21/ 00( . ) C12R 1/ 91( . ) (86) International application number: PCT/GB1985/000340 (87) International publication number: WO 1986/000927 (13.02.1986 Gazette 1986/04)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 31.07.1984 GB 19840019456 (71) Applicant: AXON HEALTHCARE LTD. Douglas, Isle of Man (GB)	(72) Inventors: STARKIE, Selby, John Cambridge CB1 5DY (GB) WILLIAMS, Gwynfor, Rees Isle of Man (GB) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)