(19)

(11)

EP 0 191 846 A1

(12)

(43) Date of publication: 27.08.1986 Bulletin 1986/35 (21) Application number: 85904390.0 (22) Date of filing: 27.08.1985

(51) International Patent Classification (IPC):  G01N 33/ 566( . ) C07K 14/ 005( . ) C07K 14/ 705( . ) C07K 16/ 00( . ) C12N 5/ 00( . ) C12N 15/ 00( . ) C12P 21/ 00( . ) G01N 33/ 577( . ) A61K 39/ 00( . ) C07K 14/ 195( . ) C07K 14/ 76( . ) C07K 16/ 42( . ) C12N 5/ 10( . ) C12N 15/ 02( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1985/001658 (87) International publication number: WO 1986/001539 (13.03.1986 Gazette 1986/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 27.08.1984 US 19840644550 (71) Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK New York, New York 10027 (US)	(72) Inventors: ERLANGER, Bernard, F. Whitestone, NY 11357 (US) CLEVELAND, William, L. New York, NY 10025 (US) (74) Representative: Henkel, Feiler, Hänzel & Partner  Möhlstrasse 37 D-81675 München D-81675 München (DE)