(19)

(11)

EP 0 192 743 A1

(12)

(43) Date of publication: 03.09.1986 Bulletin 1986/36 (21) Application number: 85904544.0 (22) Date of filing: 30.08.1985

(51) International Patent Classification (IPC):  C07K 14/ 62( . ) (86) International application number: PCT/US1985/001673 (87) International publication number: WO 1986/001540 (13.03.1986 Gazette 1986/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 31.08.1984 US 19840646573 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, Massachusetts 02140 (US)	(72) Inventors: SCHENDEL, Paul Wayland, MA 01778 (US) SEED, Brian Cambridge, MA 02138 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 P.O. Box 86 07 67 D-8000 München 86 D-8000 München 86 (DE)