(19)

(11)

EP 0 208 764 A1

(12)

(43) Date of publication: 21.01.1987 Bulletin 1987/04 (21) Application number: 86900891.0 (22) Date of filing: 08.01.1986

(51) International Patent Classification (IPC):  A61K 49/ 00( . ) A61K 9/ 127( . ) A61K 9/ 00( . ) A61K 49/ 22( . ) (86) International application number: PCT/US1986/000016 (87) International publication number: WO 1986/003938 (17.07.1986 Gazette 1986/17)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 11.01.1985 US 19850690679 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Berkeley, California 94720 (US)	(72) Inventors: CROWE, John, H. Davis, CA 95616 (US) CROWE, Lois, M. Davis, CA 95616 (US) (74) Representative: Harrison, David Christopher, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)