(19)

(11)

EP 0 215 805 A1

(12)

(43) Date of publication: 01.04.1987 Bulletin 1987/14 (21) Application number: 86900764.0 (22) Date of filing: 15.01.1986

(51) International Patent Classification (IPC):  C07K 5/ 068( . ) C07K 5/ 078( . ) C07K 5/ 087( . ) C07K 5/ 107( . ) C07K 16/ 06( . ) C07K 5/ 072( . ) C07K 5/ 083( . ) C07K 5/ 09( . ) C07K 14/ 575( . ) A61K 38/ 00( . ) (86) International application number: PCT/EP1986/000012 (87) International publication number: WO 1986/004334 (31.07.1986 Gazette 1986/17)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI NL SE (30) Priority: 18.01.1985 US 19850692711 29.11.1985 US 19850805504 29.11.1985 US 19850803452 (71) Applicant: MERCK PATENT GmbH D-64271 Darmstadt (DE)	(72) Inventor: HAHN, Gary, Scott San Diego, CA 921921 (US) (74) Representative: Armitage, Ian Michael, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)