(19)

(11)

EP 0 216 853 A1

(12)

(43) Date of publication: 08.04.1987 Bulletin 1987/15 (21) Application number: 86902113.0 (22) Date of filing: 06.03.1986

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) C12Q 1/ 68( . ) C07K 16/ 28( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1986/000450 (87) International publication number: WO 1986/005203 (12.09.1986 Gazette 1986/20)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 07.03.1985 US 19850709183 (71) Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Cambridge, MA 02142 (US)	(72) Inventors: ALPER, Seth, L. 1558 Massachusetts Avenue Cambridge, MA 02138 (US) KOPITO, Ron, R. Somerville, MA 02143 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)