(19)

(11)

EP 0 216 929 A1

(12)

(43) Date of publication: 08.04.1987 Bulletin 1987/15 (21) Application number: 86900636.0 (22) Date of filing: 13.01.1986

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) (86) International application number: PCT/JP1986/000011 (87) International publication number: WO 1986/004069 (17.07.1986 Gazette 1986/17)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 14.01.1985 JP 19850004721 21.06.1985 JP 19850136670 (71) Applicant: YAMANOUCHI PHARMACEUTICAL CO. LTD. Tokyo (JP)	(72) Inventors: OBARA, Tadashi Shinjuku-ku Tokyo 161 (JP) EZOE, Hisanori Shibuya-ku Tokyo 151 (JP) TAKEMOTO, Toshiyuki Shiki-shi Saitama 353 (JP) MORINAGA, Tetsuo Saitama 340-01 (JP) HARANAKA, Katsuyuki Omiya-shi Saitama 330 (JP) SATOMI, Nobuko Meguro-ku Tokyo 153 (JP) (74) Representative: Geering, Keith Edwin, et al  REDDIE & GROSE 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)