(19)

(11)

EP 0 223 842 A1

(12)

(43) Date of publication: 03.06.1987 Bulletin 1987/23 (21) Application number: 86903931.0 (22) Date of filing: 23.05.1986

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07K 1/ 20( . ) C07K 14/ 005( . ) C07K 14/ 705( . ) C07K 16/ 28( . ) C12P 21/ 00( . ) G01N 33/ 577( . ) C12R 1/ 91( . ) A61K 39/ 00( . ) C07K 1/ 22( . ) C07K 14/ 195( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1986/001177 (87) International publication number: WO 1986/007062 (04.12.1986 Gazette 1986/26)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.05.1985 US 19850738171 (71) Applicant: NEW YORK UNIVERSITY New York, NY 10016 (US)	(72) Inventors: KINOSHITA, Taroh New York, NY 10001 (US) MEDOF, M., Edward New York, NY 10016 (US) NUSSENZWEIG, Victor New York, NY 10012 (US) (74) Representative: Patentanwälte Grünecker, Kinkeldey, Stockmair & Partner  Maximilianstrasse 58 D-80538 München D-80538 München (DE)