(19)

(11)

EP 0 227 814 A1

(12)

(43) Date of publication: 08.07.1987 Bulletin 1987/28 (21) Application number: 86904573.0 (22) Date of filing: 18.06.1986

(51) International Patent Classification (IPC):  A61K 9/ 20( . ) A61K 9/ 22( . ) (86) International application number: PCT/US1986/001360 (87) International publication number: WO 1987/000044 (15.01.1987 Gazette 1987/01)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 02.07.1985 US 19850751125 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventor: SHAH, Ashok, C. Portage, MI 49002 (US)