(19)

(11)

EP 0 227 815 A1

(12)

(43) Date of publication: 08.07.1987 Bulletin 1987/28 (21) Application number: 86904575.0 (22) Date of filing: 27.06.1986

(51) International Patent Classification (IPC):  G01N 33/ 497( . ) C07D 487/ 00( . ) G01N 21/ 64( . ) A61K 49/ 00( . ) C07F 15/ 00( . ) G01N 21/ 76( . ) (86) International application number: PCT/US1986/001362 (87) International publication number: WO 1987/000023 (15.01.1987 Gazette 1987/01)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 03.07.1985 US 19850752262 (71) Applicant: INTERNATIONAL BIOMEDICS, INC. Bothell, WA 98335 (US)	(72) Inventors: KAHIL, Gamal-Eddin Bellevue, WA 98007 (US) GOUTERMAN, Martin, P. Seattle, WA 98102 (US) GREEN, Edmond Seattle, WA 98103 (US) (74) Representative: Arthur, Bryan Edward  Withers & Rogers 4 Dyer's Buildings Holborn London EC1N 2JT London EC1N 2JT (GB)