(19)

(11)

EP 0 229 174 A1

(12)

(43) Date of publication: 22.07.1987 Bulletin 1987/30 (21) Application number: 86904689.0 (22) Date of filing: 16.07.1986

(51) International Patent Classification (IPC):  C12N 15/ 82( . ) (86) International application number: PCT/US1986/001493 (87) International publication number: WO 1987/000551 (29.01.1987 Gazette 1987/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 16.07.1985 US 19850755774 (71) Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La Jolla California 92037 (US)	(72) Inventors: VERMA, Inder, Mohan Solana Beach, CA 92075 (US) LAMB, Christopher, John San Diego, CA 92122 (US)