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(11)

EP 0 232 373 A1

(12)

(43) Date of publication: 19.08.1987 Bulletin 1987/34 (21) Application number: 86905061.0 (22) Date of filing: 06.08.1986

(51) International Patent Classification (IPC):  C12P 29/ 00( . ) (86) International application number: PCT/US1986/001587 (87) International publication number: WO 1987/000832 (12.02.1987 Gazette 1987/04)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 08.08.1985 US 19850763740 08.08.1985 US 19850763742 09.08.1985 US 19850764275 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)

(72) Inventors: SMITH, Elizabeth, Bargmann Plainsboro, NJ 08536 (US) MUNAYYER, Hanan, Karaman West Caldwell, NJ 07006 (US) RYAN, Michael, Joseph West Milford, NJ 07480 (US) MILLER, George, Henry Montville, NJ 07045 (US) PATEL, Mahesh, Gordhandas Verona, NJ 07046 (US) HORAN, Ann, Camille Summit, NJ 07901 (US) MARQUEZ, Joseph, Anthony Montclair, NJ 07042 (US) VAUGHAN, Richard, Willis Augusta, GA 30907 (US) KALYANPOR, Manohar, Gopal F-78370 Plaisir (FR) WAITZ, Jay, Allan Portola Valley, CA 94025 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)