(19)

(11)

EP 0 232 407 A1

(12)

(43) Date of publication: 19.08.1987 Bulletin 1987/34 (21) Application number: 86905506.0 (22) Date of filing: 13.08.1986

(51) International Patent Classification (IPC):  A61K 9/ 107( . ) (86) International application number: PCT/US1986/001671 (87) International publication number: WO 1987/001035 (26.02.1987 Gazette 1987/05)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 13.08.1985 US 19850765359 (71) Applicant: CALIFORNIA BIOTECHNOLOGY, INC. Mountain View, CA 94043 (US)	(72) Inventors: VIGNE, Jean-Louis San Francisco, CA 94131 (US) KANE, John, P. Hillsborough, CA 94010 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)