(19)

(11)

EP 0 238 554 A1

(12)

(43) Date of publication: 30.09.1987 Bulletin 1987/40 (21) Application number: 86905653.0 (22) Date of filing: 11.09.1986

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 9/ 70( . ) A61K 9/ 127( . ) (86) International application number: PCT/US1986/001893 (87) International publication number: WO 1987/001938 (09.04.1987 Gazette 1987/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 27.09.1985 US 19850781147 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Berkeley, California 94720 (US)	(72) Inventors: GUY, Richard, H. Daly City, CA 94014 (US) SZOKA, Francis, C. San Francisco, CA 94116 (US) KNEPP, Victoria, M. San Francisco, CA 94117 (US) WESTER, Ronald, C. San Francisco, CA 94122 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)