(19)

(11)

EP 0 238 618 A1

(12)

(43) Date of publication: 30.09.1987 Bulletin 1987/40 (21) Application number: 86906043.0 (22) Date of filing: 28.08.1986

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61P 31/ 12( . ) C07K 14/ 03( . ) C12N 1/ 21( . ) C12N 15/ 00( . ) C12N 15/ 38( . ) G01N 33/ 569( . ) C12R 1/ 19( . ) C12R 1/ 91( . ) A61K 39/ 245( . ) A61P 31/ 22( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 39/ 00( . ) C12R 1/ 645( . ) C12R 1/ 92( . ) (86) International application number: PCT/US1986/001761 (87) International publication number: WO 1987/002058 (09.04.1987 Gazette 1987/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 04.10.1985 US 19850784787 26.11.1985 US 19850801799 26.03.1986 US 19860844113 16.07.1986 US 19860886260 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: PETROVSKIS, Erik, A. Kalamazoo, MI 49007 (US) POST, Leonard, E. Kalamazoo, MI 49007 (US) TIMMINS, James, G. Cambridge, MA 02139 (US)