(19)

(11)

EP 0 239 631 A1

(12)

(43) Date of publication: 07.10.1987 Bulletin 1987/41 (21) Application number: 86906545.0 (22) Date of filing: 02.10.1986

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) C12N 15/ 62( . ) C12P 21/ 02( . ) C07K 14/ 775( . ) C12N 15/ 85( . ) (86) International application number: PCT/US1986/002075 (87) International publication number: WO 1987/002062 (09.04.1987 Gazette 1987/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 04.10.1985 US 19850784418 04.12.1985 US 19850804692 (71) Applicant: BIOTECHNOLOGY RESEARCH PARTNERS, LTD. Mountain View California 94043 (US)	(72) Inventors: PROTTER, Andrew, A. Palo Alto, CA 94301 (US) VIGNE, Jean-Louis San Francisco, CA 94131 (US) MALLORY, Joanne, B. San Jose, CA 95121 (US) TALMADGE, Karen, D. Palo Alto, CA 94303 (US) KANE, John, P. Hillsborough, CA 94010 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)