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(11)

EP 0 240 550 A1

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(43) Date of publication: 14.10.1987 Bulletin 1987/42 (21) Application number: 86906180.0 (22) Date of filing: 26.09.1986

(51) International Patent Classification (IPC):  C07K 14/ 785( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1986/002034 (87) International publication number: WO 1987/002037 (09.04.1987 Gazette 1987/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 26.09.1985 US 19850781130 15.08.1986 US 19860897183 (71) Applicants: GENETICS INSTITUTE, INC. Cambridge, Massachusetts 02140 (US) BRIGHAM AND WOMEN'S HOSPITAL Boston, Massachusetts 02115 (US)	(72) Inventors: TAEUSCH, H., William, Jr. Brookline, MA 02146 (US) JACOBS, Kenneth, A. Newton, MA 02160 (US) STEINBRINK, D., Randall Belmont, MA 02178 (US) FLOROS, Joanna West Roxbury, MA 02132 (US) PHELPS, Davis, S. West Roxbury, MA 02132 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)