(19)

(11)

EP 0 243 370 A1

(12)

(43) Date of publication: 04.11.1987 Bulletin 1987/45 (21) Application number: 86901372.0 (22) Date of filing: 02.02.1986

(51) International Patent Classification (IPC):  C07C 69/ 54( . ) G01N 33/ 538( . ) G01N 33/ 558( . ) C12Q 1/ 00( . ) G01N 33/ 543( . ) G01N 37/ 00( . ) (86) International application number: PCT/EP1986/000055 (87) International publication number: WO 1986/004683 (14.08.1986 Gazette 1986/18)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 08.02.1985 IT 19850019443 (71) Applicant: BOEHRINGER BIOCHEMIA ROBIN S.p.A. I-20126 Milan (IT)	(72) Inventors: IACCHERI, Ennio I-20126 Milan (IT) PIRO, Paola I-20126 Milan (IT) MANZATI, Claudio I-20126 Milan (IT) (74) Representative: Bianchetti, Giuseppe  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milan I-20122 Milan (IT)