(19)

(11)

EP 0 243 372 A1

(12)

(43) Date of publication: 04.11.1987 Bulletin 1987/45 (21) Application number: 86902138.0 (22) Date of filing: 11.03.1986

(51) International Patent Classification (IPC):  C12Q 1/ 14( . ) G01N 33/ 569( . ) C12Q 1/ 24( . ) (86) International application number: PCT/US1986/000481 (87) International publication number: WO 1987/001393 (12.03.1987 Gazette 1987/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 09.09.1985 US 19850773586 (71) Applicant: ALLEGHENY-SINGER RESEARCH INSTITUTE Pittsburgh, PA 15212-9986 (US)	(72) Inventor: SLIFKIN, Malcolm Pittsburgh, PA 15217 (US) (74) Representative: Prins, Hendrik Willem, et al  Arnold & Siedsma, Advocaten en Octrooigemachtigden, Sweelinckplein 1 NL-2517 GK Den Haag NL-2517 GK Den Haag (NL)