(19)

(11)

EP 0 243 448 A1

(12)

(43) Date of publication: 04.11.1987 Bulletin 1987/45 (21) Application number: 86906566.0 (22) Date of filing: 07.10.1986

(51) International Patent Classification (IPC):  C07K 16/ 40( . ) C12N 9/ 64( . ) (86) International application number: PCT/US1986/002111 (87) International publication number: WO 1987/002463 (23.04.1987 Gazette 1987/09)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 09.10.1985 US 19850785913 03.10.1986 US 19860915004 (71) Applicant: FLORIDA ATLANTIC UNIVERSITY Boca Raton, FL 33431 (US)	(72) Inventors: HARTMANN, James, X. Boca Raton, FL 33431 (US) LYKO, Henry, C. Lauderhill, FL 33313 (US) (74) Representative: Weinhold, Peter, Dr.  Patentanwälte Dr. Weinhold, Dannenberg, Dr. Gudel, Schubert Siegfriedstrasse 8 D-80803 München D-80803 München (DE)