(19)

(11)

EP 0 244 471 A1

(12)

(43) Date of publication: 11.11.1987 Bulletin 1987/46 (21) Application number: 86907047.0 (22) Date of filing: 23.10.1986

(51) International Patent Classification (IPC):  C07H 21/ 00( . ) C12Q 1/ 70( . ) C07H 23/ 00( . ) (86) International application number: PCT/US1986/002241 (87) International publication number: WO 1987/002708 (07.05.1987 Gazette 1987/10)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.10.1985 US 19850790833 (71) Applicant: SISKA DIAGNOSTICS,INC. La Jolla, CA 92037 (US)	(72) Inventors: MUSSO, Gary, Fred San Diego, CA 92110 (US) GHOSH, Soumitra, Shankar San Diego, CA 92121 (US) GINGERAS, Thomas, Raymond Encinitas, CA 92024 (US) (74) Representative: Bizley, Richard Edward, et al  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)