(19)

(11)

EP 0 245 368 A1

(12)

(43) Date of publication: 19.11.1987 Bulletin 1987/47 (21) Application number: 86906690.0 (22) Date of filing: 27.10.1986

(51) International Patent Classification (IPC):  A61K 31/ 165( . ) A61K 31/ 16( . ) (86) International application number: PCT/US1986/002298 (87) International publication number: WO 1987/002583 (07.05.1987 Gazette 1987/10)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 29.10.1985 US 19850792610 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventor: WEINREB, Herman, J. New York, NY 10028 (US) (74) Representative: Weinhold, Peter, Dr.  Patentanwälte Dr. Weinhold, Dannenberg, Dr. Gudel, Schubert Siegfriedstrasse 8 D-80803 München D-80803 München (DE)