(19)

(11)

EP 0 245 497 A1

(12)

(43) Date of publication: 19.11.1987 Bulletin 1987/47 (21) Application number: 87900378.0 (22) Date of filing: 12.11.1986

(51) International Patent Classification (IPC):  C12N 1/ 32( . ) C12N 15/ 70( . ) C12N 15/ 52( . ) C12P 13/ 06( . ) (86) International application number: PCT/US1986/002440 (87) International publication number: WO 1987/002984 (21.05.1987 Gazette 1987/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 12.11.1985 US 19850797421 16.10.1986 US 19860920146 (71) Applicant: AMERICAN BIOGENETICS CORPORATION Irvine, CA 92715 (US)	(72) Inventors: HATFIELD, G., Wesley Corona del Mar, CA 92625 (US) SHARP, Janice, A. Irvine, CA 92714 (US) MOYED, Harris, S. Irvine, CA 92715 (US) LITTLE, Robert Irvine, CA 92714 (US) (74) Representative: Rushton, Ronald, et al  SOMMERVILLE & RUSHTON 11 Holywell Hill St. Albans Hertfordshire AL1 1EZ St. Albans Hertfordshire AL1 1EZ (GB)