(19)

(11)

EP 0 250 477 A1

(12)

(43) Date of publication: 07.01.1988 Bulletin 1988/01 (21) Application number: 86906886.0 (22) Date of filing: 21.11.1986

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) (86) International application number: PCT/GB1986/000711 (87) International publication number: WO 1987/003205 (04.06.1987 Gazette 1987/12)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 22.11.1985 GB 19850028761 (71) Applicant: CORAL SOCIEDADE BRASILIERA DE PESQUISAS E DESENVOLVIMENTO LTDA. 01452 Sao Paulo (BR)	(72) Inventor: STARKIE, Selby, John Riverside Cottages Cambridgeshire CB5 9JB (GB) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)