(19)

(11)

EP 0 250 530 A1

(12)

(43) Date of publication: 07.01.1988 Bulletin 1988/01 (21) Application number: 87900230.0 (22) Date of filing: 23.12.1986

(51) International Patent Classification (IPC):  C07C 323/ 60( . ) C07C 67/ 00( . ) C07C 313/ 00( . ) A61K 31/ 185( . ) C07C 239/ 00( . ) C07C 323/ 47( . ) (86) International application number: PCT/GB1986/000791 (87) International publication number: WO 1987/004152 (16.07.1987 Gazette 1987/15)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 30.12.1985 GB 19850031838 (71) Applicant: THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)	(72) Inventors: KNEEN, Geoffrey South Eden Park Road Beckenham, Kent (GB) JACKSON, William, Paul Beckenham, Kent (GB) ISLIP, Peter, John Beckenham, Kent (GB) (74) Representative: Cresswell, Thomas Anthony  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)