(19)

(11)

EP 0 258 412 A1

(12)

(43) Date of publication: 09.03.1988 Bulletin 1988/10 (21) Application number: 87901944.0 (22) Date of filing: 20.02.1987

(51) International Patent Classification (IPC):  C07H 19/ 06( . ) (86) International application number: PCT/US1987/000398 (87) International publication number: WO 1987/004929 (27.08.1987 Gazette 1987/19)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 20.02.1986 US 19860831278 (71) Applicants: GREER, Sheldon B. University of Miami P.O. Box 016960 Miami, FL 33101 (US) PARKS, Wade P. University of Miami P.O. Box 016960 Miami, FL 33101 (US)	(72) Inventors: GREER, Sheldon B. University of Miami P.O. Box 016960 Miami, FL 33101 (US) PARKS, Wade P. University of Miami P.O. Box 016960 Miami, FL 33101 (US)