(19)

(11)

EP 0 259 484 A1

(12)

(43) Date of publication: 16.03.1988 Bulletin 1988/11 (21) Application number: 87902254.0 (22) Date of filing: 11.03.1987

(51) International Patent Classification (IPC):  A61L 27/ 42( . ) A61F 2/ 28( . ) A61F 2/ 02( . ) (86) International application number: PCT/US1987/000548 (87) International publication number: WO 1987/005521 (24.09.1987 Gazette 1987/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 11.03.1986 US 19860838533 (71) Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY Newark, New Jersey 07107-3007 (US)	(72) Inventors: PARSONS, John, R. Perth Amboy, NJ 08861 (US) ALEXANDER, Harold Short Hills, NJ 07078 (US) WEISS, Andrew, B. Short Hills, NJ 07078 (US)