(19)

(11)

EP 0 261 168 A1

(12)

(43) Date of publication: 30.03.1988 Bulletin 1988/13 (21) Application number: 87901809.0 (22) Date of filing: 05.02.1987

(51) International Patent Classification (IPC):  C12N 7/ 04( . ) A61K 39/ 215( . ) (86) International application number: PCT/US1987/000216 (87) International publication number: WO 1987/004624 (13.08.1987 Gazette 1987/18)

(84) Designated Contracting States: DE FR GB NL (30) Priority: 06.02.1986 US 19860826638 (71) Applicant: CORNELL RESEARCH FOUNDATION, INC. Ithaca, N.Y. 14850 (US)	(72) Inventors: BALDWIN, Charles, A. Stillwater, OK 74075 (US) SCOTT, Fredric, W. Brooktondale, NY 14817 (US) (74) Representative: Kraus, Walter, Dr., et al  Patentanwälte Kraus, Weisert & Partner Thomas-Wimmer-Ring 15 D-80539 München D-80539 München (DE)