(19)

(11)

EP 0 269 724 A1

(12)

(43) Date of publication: 08.06.1988 Bulletin 1988/23 (21) Application number: 87904277.0 (22) Date of filing: 16.06.1987

(51) International Patent Classification (IPC):  C07K 14/ 00( . ) C12N 9/ 64( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) C12N 1/ 20( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) (86) International application number: PCT/GB1987/000420 (87) International publication number: WO 1987/007907 (30.12.1987 Gazette 1987/29)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.06.1986 GB 19860014722 07.08.1986 GB 19860019272 (71) Applicant: CELLTECH LIMITED Slough Berkshire SL1 4EN (GB)	(72) Inventors: DOCHERTY, Andrew, James, Penrose Middlesex TW12 1DD (GB) MURPHY, Gillian Cambridge CB2 5UV (GB) (74) Representative: Votier, Sidney David, et al  CARPMAELS & RANSFORD 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)