(19)

(11)

EP 0 271 573 A1

(12)

(43) Date of publication: 22.06.1988 Bulletin 1988/25 (21) Application number: 87904769.0 (22) Date of filing: 25.06.1987

(51) International Patent Classification (IPC):  A61K 31/ 475( . ) C07D 519/ 00( . ) A61P 35/ 00( . ) (86) International application number: PCT/US1987/001566 (87) International publication number: WO 1988/000198 (14.01.1988 Gazette 1988/02)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 26.06.1986 US 19860879094 (71) Applicant: HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. Fort Pierce, FL 33450 (US)	(72) Inventors: HIGA, Tatsuo Naha, Okinawa (JP) SAKAI, Ryuichi Vero Beach, FL 32962 (US) (74) Representative: Marchant, James Ian, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)