(19)

(11)

EP 0 272 309 A1

(12)

(43) Date of publication: 29.06.1988 Bulletin 1988/26 (21) Application number: 87904454.0 (22) Date of filing: 23.06.1987

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 1/ 20( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C12P 21/ 00( . ) A61K 38/ 00( . ) C07K 1/ 22( . ) C07K 14/ 575( . ) C07K 16/ 26( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1987/001470 (87) International publication number: WO 1988/000208 (14.01.1988 Gazette 1988/02)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.06.1986 US 19860878063 (71) Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La Jolla California 92037 (US)	(72) Inventors: SPIESS, Joachim Encinitas, CA 92024 (US) RIVIER, Jean, Edouard, Frederic La Jolla, CA 92037 (US) BARDIN, Wayne, C. New York, NY 10021 (US) VALE, Wylie, Walker, Jr. La Jolla, CA 92037 (US) (74) Representative: Lawrence, Malcolm Graham, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Bakers Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)