(19)

(11)

EP 0 273 971 A1

(12)

(43) Date of publication: 13.07.1988 Bulletin 1988/28 (21) Application number: 87904810.0 (22) Date of filing: 17.07.1987

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61K 39/ 395( . ) C07K 14/ 00( . ) C07K 14/ 445( . ) C07K 16/ 20( . ) C12P 21/ 00( . ) C12P 21/ 08( . ) A61K 39/ 00( . ) C12R 1/ 91( . ) A61K 39/ 015( . ) C07K 7/ 06( . ) C07K 14/ 44( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) C12R 1/ 90( . ) (86) International application number: PCT/AU1987/000226 (87) International publication number: WO 1988/000597 (28.01.1988 Gazette 1988/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.07.1986 AU 19860006983 24.03.1987 AU 19870001046 (71) Applicant: SARAMANE PTY. LTD. Parkville, VIC 3052 (AU)	(72) Inventors: KARA, Ursula, Anna, Kate Kelvin Grove, QLD 4059 (AU) STENZEL, Deborah, Joan Ferny Hills, QLD 4055 (AU) BUSHELL, Gillian, Robin Bardon, QLD 4065 (AU) GEYSEN, Hendrik, Mario Knoxfield, VIC 3180 (AU) SAUL, Allan, James The Gap, QLD 4061 (AU) (74) Representative: Holmes, Michael John, et al  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)