(19)
(11) EP 0 277 289 B8

(12) CORRECTED NEW EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B2)

(48) Corrigendum issued on:
21.05.2003 Bulletin 2003/21

(45) Date of publication and mentionof the opposition decision:
02.04.2003 Bulletin 2003/14

(45) Mention of the grant of the patent:
01.04.1992 Bulletin 1992/14

(21) Application number: 87116556.9

(22) Date of filing: 10.11.1987
(51) International Patent Classification (IPC)7: A61K 38/16

(54)

Extra pure semi-synthetic blood substitute

Hochreines, halbsynthetisches Blutsurrogat

Substitut du sang, semi-synthétique, extrêmement pur

(84) Designated Contracting States:
AT BE CH DE ES FR GB GR IT LI LU NL SE

(30) Priority: 10.11.1986 US 928345
13.10.1987 US 107421

(43) Date of publication of application:
10.08.1988 Bulletin 1988/32

(73) Proprietor: BIOPURE CORPORATION
Cambridge, MA 02141 (US)

(72) Inventors:
  • Rausch, Carl W.
    Providence Rhode Island (US)
  • Feola, Mario
    Lubbock Texas 79430 (US)

(74) Representative: Holdcroft, James Gerald, Dr. et al
Graham Watt & Co. St. Botolph's House 7-9 St. Botolph's Road
Sevenoaks, Kent TN13 3AJ
Sevenoaks, Kent TN13 3AJ (GB)


(56) References cited: : 
EP-A- 0 195 558
US-A- 4 001 401
US-A- 4 584 130
 WO-A-84/04248
US-A- 4 526 715
   
  • CHEMICAL ABSTRACTS, vol. 105, no 14, 6th October 1986, page 357, abstract no. 120582z, Columbus, Ohio, US; C.J.C. HSIA: "ATP-hemoglobin purification by ATP-agarose affinity chromatography", & J. CHROMATOGR. 1986, 381(1), 153-7
  • Science, 172, p.1049-50(1971);
  • Pflügers Archiv, 389, p.219-25(1981)
  • Biol. chem., 259, p.10841-44(1984);
  • KABI-VITRUM brochure "Endotoxin" (1987)
  • Surg., Gynec. & Obstetr., 165, pgs 212-221 (1988)
  • Feola, M. et al, Surgery, 157 (5), pp. 399-408, (1983)
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification