(19)

(11)

EP 0 282 550 A1

(12)

(43) Date of publication: 21.09.1988 Bulletin 1988/38 (21) Application number: 87906169.0 (22) Date of filing: 11.09.1987

(51) International Patent Classification (IPC):  C12P 21/ 02( . ) A61P 3/ 08( . ) C07K 14/ 62( . ) C12N 15/ 81( . ) C12R 1/ 865( . ) A61K 38/ 28( . ) C07K 14/ 575( . ) C12N 9/ 02( . ) A61K 38/ 00( . ) (86) International application number: PCT/DK1987/000111 (87) International publication number: WO 1988/002005 (24.03.1988 Gazette 1988/07)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 12.09.1986 DK 19860004377 (71) Applicant: NORDISK GENTOFTE A/S DK-2820 Gentofte (DK)	(72) Inventors: BALSCHMIDT, Per DK-3060 Espergaerde (DK) HANSEN, Finn, Benned DK-2100 Copenhagen (DK) HEJNAES, Kim, Ry DK-2800 Lyngby (DK) CLAUSEN, Ib, Groth DK-1352 Copenhagen (DK) (74) Representative: Patentanwälte Beetz - Timpe - Siegfried Schmitt-Fumian - Mayr  Steinsdorfstrasse 10 D-80538 München D-80538 München (DE)