(19)

(11)

EP 0 282 581 A1

(12)

(43) Date of publication: 21.09.1988 Bulletin 1988/38 (21) Application number: 87906712.0 (22) Date of filing: 18.09.1987

(51) International Patent Classification (IPC):  G01N 33/ 574( . ) (86) International application number: PCT/US1987/002419 (87) International publication number: WO 1988/002117 (24.03.1988 Gazette 1988/07)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 19.09.1986 US 19860909225 (71) Applicant: SCRIPPS CLINIC AND RESEARCH FOUNDATION La Jolla California 92037 (US)	(72) Inventors: CHERESH, David, A. La Jolla, CA 92037 (US) REISFELD, Ralph, A. La Jolla, CA 92037 (US) (74) Representative: Fisher, Adrian John, et al  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)