(19)

(11)

EP 0 286 642 A1

(12)

(43) Date of publication: 19.10.1988 Bulletin 1988/42 (21) Application number: 87900593.0 (22) Date of filing: 17.12.1986

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) (86) International application number: PCT/US1986/002788 (87) International publication number: WO 1987/003911 (02.07.1987 Gazette 1987/14)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.12.1985 US 19850809971 17.12.1985 US 19850809992 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, Massachusetts 02140 (US)	(72) Inventors: COLLINS, Mary Natick, MA 01760 (US) DOUGHERTY, Joseph, P. Somerville, MA 02143 (US) FRITSCH, Edward, Francis Concord, MA 01742 (US) JACOBS, Kenneth, A. Newton, MA 02160 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)