(19)

(11)

EP 0 288 547 A1

(12)

(43) Date of publication: 02.11.1988 Bulletin 1988/44 (21) Application number: 87907654.0 (22) Date of filing: 03.11.1987

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 5/ 10( . ) A01H 5/ 00( . ) C12N 15/ 82( . ) (86) International application number: PCT/US1987/002888 (87) International publication number: WO 1988/003564 (19.05.1988 Gazette 1988/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 03.11.1986 US 19860926629 (71) Applicant: BIOTECHNICA INTERNATIONAL, INC. Cambridge Massachusetts 02140 (US)	(72) Inventors: BUCHANAN-WOLLASTON, Vicky Concord, MA 01742 (US) CANNON, Frank, S. Lexington, MA 02173 (US) (74) Representative: Deans, Michael John Percy, et al  Lloyd Wise, Tregear & CO. Norman House 105-109 Strand London WC2R OAE London WC2R OAE (GB)