(19)

(11)

EP 0 289 508 A1

(12)

(43) Date of publication: 09.11.1988 Bulletin 1988/45 (21) Application number: 87900529.0 (22) Date of filing: 12.12.1986

(51) International Patent Classification (IPC):  C07K( . ) C12N 1/ 16( . ) C12N 5/ 00( . ) C12N 15/ 00( . ) C12N 15/ 58( . ) C12N 9/ 64( . ) C12N 1/ 20( . ) C12N 9/ 72( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1986/002684 (87) International publication number: WO 1987/003906 (02.07.1987 Gazette 1987/14)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 20.12.1985 US 19850811607 19.09.1986 US 19860909482 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: MAROTTI, Keith, R. Kalamazoo, MI 49008 (US) REHBERG, Edward, F. Kalamazoo, MI 49008 (US) THERIAULT, Nicole, Y. Kalamazoo, MI 49001 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)