(19)

(11)

EP 0 289 546 A1

(12)

(43) Date of publication: 09.11.1988 Bulletin 1988/45 (21) Application number: 87907123.0 (22) Date of filing: 04.11.1987

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61K 39/ 395( . ) C07K 14/ 435( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) C12P 21/ 00( . ) G01N 33/ 563( . ) G01N 33/ 577( . ) C12R 1/ 91( . ) A61K 39/ 00( . ) C07K 1/ 22( . ) C07K 14/ 705( . ) C07K 16/ 46( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 574( . ) A61K 38/ 00( . ) (86) International application number: PCT/GB1987/000781 (87) International publication number: WO 1988/003565 (19.05.1988 Gazette 1988/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 05.11.1986 GB 19860026412 (71) Applicant: NATIONAL RESEARCH DEVELOPMENT CORPORATION London SE1 6BU (GB)	(72) Inventors: CLARK, Michael, Ronald Cambridge CB1 2PY (GB) WALDMANN, Herman Cambridge CB4 2ED (GB) (74) Representative: Stephenson, Gerald Frederick  Patents Department British Technology Ltd 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)