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(11)

EP 0 290 516 A1

(12)

(43) Date of publication: 17.11.1988 Bulletin 1988/46 (21) Application number: 87907365.0 (22) Date of filing: 02.10.1987

(51) International Patent Classification (IPC):  A61K 31/ 575( . ) A61K 31/ 685( . ) A61K 38/ 17( . ) C07K 16/ 18( . ) C12N 15/ 72( . ) A61K 31/ 66( . ) A61K 35/ 42( . ) C07K 14/ 785( . ) C12N 9/ 00( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1987/002536 (87) International publication number: WO 1988/003170 (05.05.1988 Gazette 1988/10)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.10.1986 WO 1986US02258 08.12.1986 US 19860939206 10.06.1987 US 19870060719 01.10.1987 US 19870101680 (71) Applicants: WHITSETT, Jeffrey A. Cincinnati, OH 45229 (US) FOX, J. Lawrence Lake Bluff, IL 60044 (US) PILOT-MATIAS, Tami J. Libertyville, IL 60048 (US) MEUTH, Joseph L. Mundelein, IL 60060 (US) SARIN, Virender K. Libertyville, IL 60048 (US)

(72) Inventors: WHITSETT, Jeffrey A. Cincinnati, OH 45229 (US) FOX, J. Lawrence Lake Bluff, IL 60044 (US) PILOT-MATIAS, Tami J. Libertyville, IL 60048 (US) MEUTH, Joseph L. Mundelein, IL 60060 (US) SARIN, Virender K. Libertyville, IL 60048 (US) (74) Representative: Brown, John David, et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)