(19)

(11)

EP 0 296 171 A1

(12)

(43) Date of publication: 28.12.1988 Bulletin 1988/52 (21) Application number: 87901966.0 (22) Date of filing: 03.03.1987

(51) International Patent Classification (IPC):  G01N 33/ 573( . ) (86) International application number: PCT/US1987/000432 (87) International publication number: WO 1987/005396 (11.09.1987 Gazette 1987/20)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 03.03.1986 US 19860835283 (71) Applicant: BRIGHAM AND WOMEN'S HOSPITAL Boston, Massachusetts 02115 (US)	(72) Inventors: SPRAGG, Jocelyn Jamaica Plain, MA 01230 (US) AUSTEN, K., Frank Wellsley, MA 02181 (US) (74) Representative: Kearney, Kevin David Nicholas  KILBURN & STRODE 30 John Street London, WC1N 2DD London, WC1N 2DD (GB)