(19)

(11)

EP 0 302 862 A1

(12)

(43) Date of publication: 15.02.1989 Bulletin 1989/07 (21) Application number: 87902004.0 (22) Date of filing: 13.03.1987

(51) International Patent Classification (IPC):  A61K 38/ 21( . ) A61P 35/ 00( . ) (86) International application number: PCT/US1987/000504 (87) International publication number: WO 1987/005518 (24.09.1987 Gazette 1987/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.03.1986 US 19860840302 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: TROTTA, Paul, Philip Rutherford, NJ 07070 (US) NAGABHUSHAN, Tattanahali, L. Parsippany, NJ 07054 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)