(19)

(11)

EP 0 304 461 A1

(12)

(43) Date of publication: 01.03.1989 Bulletin 1989/09 (21) Application number: 88902172.0 (22) Date of filing: 09.03.1988

(51) International Patent Classification (IPC):  G01N 21/ 47( . ) G01N 21/ 64( . ) G01N 33/ 553( . ) G01N 21/ 55( . ) G01N 33/ 543( . ) (86) International application number: PCT/GB1988/000176 (87) International publication number: WO 1988/007202 (22.09.1988 Gazette 1988/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 10.03.1987 GB 19870005650 (71) Applicant: ARES-SERONO RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP Boston Massachusetts 02109 (US)	(72) Inventors: SAWYERS, Craig, George Eynesbury, St. Neots Cambridgeshire (GB) DRAKE, Rosemary, Ann, Lucy Great Chishill Royston Hertfordshire (GB) (74) Representative: Vannini, Mario  c/o Istituto Farmacologico Serono Spa Via Casilina, 125 I-00176 Roma I-00176 Roma (IT)