(19)

(11)

EP 0 304 481 A1

(12)

(43) Date of publication: 01.03.1989 Bulletin 1989/09 (21) Application number: 88903496.0 (22) Date of filing: 23.02.1988

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 577( . ) C07K 16/ 18( . ) C12P 21/ 00( . ) G01N 33/ 53( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1988/000578 (87) International publication number: WO 1988/006620 (07.09.1988 Gazette 1988/20)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 04.03.1987 US 19870021466 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventors: KEMENY, Eva New York, NY 10021 (US) FILLIT, Howard New York, NY 10021 (US) ZABRISKIE, John, B. New York, NY 10021 (US) (74) Representative: Weinhold, Peter, Dr.  Patentanwälte Dr. Weinhold, Dannenberg, Dr. Gudel, Schubert Siegfriedstrasse 8 D-80803 München D-80803 München (DE)